We examine negotiations for six international treaties and agreements to determine the influence that business had on the U.S. government’s position. The treaties: The Kyoto Treaty on Global Warming, North American Free Trade Agreement, OECD Anti-Bribery Agreement, Air Crash Liability Treaty, Law of the Sea Treaty and the Infant Formula Agreement. Business lobbying for these treaties had a strong influence on the U.S. position under all administrations, and that impact has been greater with Republican presidents.