A great number of studies concerning Greece and other countries have indicated that there are important differences in productivity of economic sectors amongst the different regions. This article focuses on the enterprises that employ more than 20 persons, analyses the observed differences in the productivity of the secondary sector and investigates the influence of technology on the configuration of enterprises??productivity. The spatial scale of analyses is the one defined by the Greek prefectural administrative level. The basic determinant factors of productivity are concretely described and the relationships between technology and productivity and between technology and geographical distance are estimated. The article concludes by commenting on both the existing spatial differences in productivity and the diffusion of technology in the light of their influence on regional inequalities in Greece.