The author analyzes the model of Strategic Interest Analysis (SIA) as a fundamental tool that leaders can profitably use in developing productive strategies relevant for the emerging organizations in the new millennium. The author explains the role of SIA in developing mission, philosophy, and strategic intent of an organization. He identifies internal as well as external challenges facing large organizations and the need for aligning vision and organizational culture in an emerging information economy. Guidelines in developing SIA and strategic vision skills are included, as well as critical skills needed for developing interest-based leadership.