Industry clusters have proved critical for a region’s economic prosperity and a nation’s overall competitiveness. This study aims to evaluate and compare competitiveness performance of two select industry clusters from India viz. Pithampur Auto Cluster and Indore Pharma Cluster. For this purpose, the study has developed a comprehensive framework and a simplified methodology that incorporate both quantitative as well as qualitative data on various aspects of cluster competitiveness. It can be used as a foundation for future works related to assessing competitiveness of the clusters.